{"id":7700,"date":"2020-11-05T11:31:13","date_gmt":"2020-11-05T11:31:13","guid":{"rendered":"https:\/\/www.innovationnewsnetwork.com\/?p=7700"},"modified":"2020-11-05T11:31:13","modified_gmt":"2020-11-05T11:31:13","slug":"patients-with-a-rare-bowel-cancer-could-benefit-from-immunotherapy","status":"publish","type":"post","link":"https:\/\/www.innovationnewsnetwork.com\/patients-with-a-rare-bowel-cancer-could-benefit-from-immunotherapy\/7700\/","title":{"rendered":"Patients with a rare bowel cancer could benefit from immunotherapy"},"content":{"rendered":"<h2>A new study conducted at the University of Birmingham, UK, has revealed that patients suffering from a rare type of bowel cancer could be treated using immunotherapy.<\/h2>\n<p>Around 1% of patients suffering from bowel cancer experience colorectal peritoneal metastasis. This means that the cancer has spread to the lining of their abdomen, known as the peritoneal cavity.<\/p>\n<p>This type of spread in bowel cancer patients carries a very poor prognosis and most patients do not survive beyond 12 months from diagnosis. Conventional chemotherapy is ineffective, and current treatment consists of extensive surgery, which is not always successful.<\/p>\n<p>In a new study, funded by the Good Hope Hospital Charity, researchers from the University of Birmingham analysed the specific tumour biology of patients suffering from colorectal peritoneal metastasis.<\/p>\n<p>As published in <a href=\"https:\/\/www.nature.com\/articles\/s41598-020-75844-6\" target=\"_blank\" rel=\"noopener noreferrer\"><em>Scientific <\/em>Reports<\/a>, the team discovered that the tumours of the patients that took part in this research carry a specific mutation that makes them sensitive to immunotherapy.<\/p>\n<p>Lead author, Professor Andrew Beggs from the University of Birmingham\u2019s Institute of Cancer and Genomic Sciences, said: \u201cWe have found that approximately 50% of patients with colorectal peritoneal metastasis have a type of genetic change, called hypermutation.<\/p>\n<p>\u201cThis means they may be sensitive to <a href=\"https:\/\/www.innovationnewsnetwork.com\/3d-printed-hydrogel-to-grow-t-cells-for-cancer-immunotherapy\/6970\/\">immunotherapy<\/a> as this type of treatment has good results in other patient groups with hypermutations. We also found potential sensitivity to a drug called a Porcupine inhibitor, based on another genetic marker identified in these patients.\u201d<\/p>\n<p>The research team will now begin to organise an international clinical trial to further examine the use of immunotherapy in treating patients with colorectal peritoneal metastasis. Beggs continued: \u201cThis is the first study of its kind in the world for patients with colorectal peritoneal metastasis, and our results have shown this could provide a potentially curative option for patients given the responses we have seen to immunotherapy in other cancers.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A new study conducted at the University of Birmingham, UK, has revealed that patients suffering from a rare type of bowel cancer could be treated using immunotherapy. Around 1% of patients suffering from bowel cancer experience colorectal peritoneal metastasis. This means that the cancer has spread to the lining of their abdomen, known as the [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":7701,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[10551],"tags":[768],"acf":[],"yoast_head":"\n<title>Patients with a rare bowel cancer could benefit from immunotherapy<\/title>\n<meta name=\"description\" content=\"A study conducted at the University of Birmingham has revealed that patients suffering from a rare bowel cancer could be treated using immunotherapy.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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