11 <\/sup><\/p>\nMany childhood BT survivors are confronted with significant educational difficulties. In a Finnish study with 44 school-aged childhood BT survivors, 32% received some type of special education.12<\/sup> The need for special education seemed to be higher with embryonal tumour survivors, with approximately three fourth of them attending some special education.11,13<\/sup> Other survivor groups especially at risk for academic decline are young children diagnosed before seven years of age and children with mutism.14,15<\/sup> In a report from childhood cancer survivor study group, siblings were more likely to graduate from college than childhood BT survivors with a relative risk of 1.4.10<\/sup> A recent publication from Sweden showed that children diagnosed with a BT (N=475) before their 15th birthday (in 1988-1996), performed worse in such subjects as mother tongue, mathematics, and English as a foreign language compared to controls, and they also had delayed graduation to a greater extent.16 <\/sup><\/p>\nThe frequency of health-related unemployment has been reported to be 25% for BT survivors and 1.8% for their siblings.17<\/sup> A similar pattern has been seen in the frequency of people unemployed but seeking work, with figures being 10% and 2.7%, respectively. Factors found to be associated with unemployment of BT survivors are cranial irradiation \u226525Gy, female gender, increasing time since diagnosis, recurrence, and secondary cancer.17<\/sup> In Sweden, it has been reported that 14% of young adults with a history of childhood BT receive handicap allowance and 23% receive disability pension.18<\/sup> The frequencies among the age matched general population were 0.6% and 2.5%.<\/p>\nResults from nation-wide registry-based studies in Finland<\/h3>\n
Ahom\u00e4ki et al studied new psychiatric diagnoses in five-year survivors of childhood cancer and reported that risk for organic memory dysfunction and disorders of mood, anxiety and personality were elevated in BT survivors compared with sibling controls.19<\/sup> When the group analysed first antidepressant (AD) purchases in five-year survivors, all diagnostic groups, also BT survivors, showed higher hazard ratios for AD purchases than sibling controls.20<\/sup> In another population-based study from Finland, 19.7% of childhood BT survivors were prematurely retired compared with 1.7% in an age-matched control group.21<\/sup> In that study, the proportion of those BT-survivors with no education after comprehensive school was higher than in controls (33.5% vs. 23.0%), but OR for unemployment was not significantly elevated.<\/p>\nFurthermore, in a study of patients diagnosed with a BT at the age of zero to 15 years, between 1970 and 2004, and surviving at least five-years, late new morbidity was assessed using the Hospital Discharge Registry data.22<\/sup> The five-year survivors had a significantly increased hazard ratio \u2013 such as for psychiatric disorders (HR 1.8), cognitive and developmental disorders (HR 16.6), neurological diseases (HR 9.8), and disorders of vision and hearing (HR 10.5), compared with the sibling cohort. However, radiation treatment did not explain all of the excess morbidity.<\/p>\nIn a small group of five-year BT-survivors, it was shown that survivors had an impaired QOL in several dimensions, such as speech and usual activities.23 <\/sup>The qualitative interview of the same survivors revealed that the most important aspects having effect on their QOL were positive mental growth, negative conceptions concerning illness, living one day at a time, age at diagnosis, time since diagnosis, social relationships, learning disabilities and limitations in vocational opportunities, limitations in independent life, and changed understanding of the term \u2018health\u2019.23 <\/sup><\/p>\nWe can conclude that paediatric BT survivors have significant neurocognitive and psychiatric sequelae that also affect their later QOL. This should motivate us to organise adequate, systematic follow-up procedures after BT in childhood. The survivors seem to assess social aspects to be more important than functionality for their QOL. Thus, interventions for social difficulties should be more actively developed, too.<\/p>\n