{"id":5509,"date":"2020-06-12T11:00:08","date_gmt":"2020-06-12T10:00:08","guid":{"rendered":"https:\/\/www.innovationnewsnetwork.com\/?p=5509"},"modified":"2020-06-12T09:46:06","modified_gmt":"2020-06-12T08:46:06","slug":"scientists-reprogramme-ancient-enzyme-for-sustainable-biotechnology","status":"publish","type":"post","link":"https:\/\/www.innovationnewsnetwork.com\/scientists-reprogramme-ancient-enzyme-for-sustainable-biotechnology\/5509\/","title":{"rendered":"Scientists reprogramme ancient enzyme for sustainable biotechnology"},"content":{"rendered":"<h2>A team of researchers led by Uppsala University, Sweden, have resurrected and reprogrammed an ancient enzyme that can be used to develop sustainable biotechnologies.<\/h2>\n<p>The team suggest that the billion-year-old enzyme can be reprogrammed to help scientists develop a variety of sustainable biotechnologies, such as bioreactors and toxin degrading mechanisms. \u201cWe use software to simulate billions of years of evolution, and we were actually able to develop an effective enzyme that can catalyse a completely new reaction. It\u2019s incredibly exciting,\u201d said Lynn Kamerlin, who is leading the research team at <a href=\"https:\/\/www.uu.se\/en\" target=\"_blank\" rel=\"noopener noreferrer\">Uppsala University<\/a>.<\/p>\n<h3>The power of enzymes<\/h3>\n<p>Most enzymes work as <a href=\"https:\/\/www.innovationnewsnetwork.com\/chemicals-industry\/924\/\">catalysts for specific chemical reactions<\/a>, serving an important function in many biological processes. Within biotechnology, intensive studies are being conducted to develop new enzymes that can catalyse new reactions for green chemistry, sustainable catalysis, and the chemical breakdown of environmentally toxic substances.<\/p>\n<p>Scientists from Uppsala University and <a href=\"https:\/\/www.ugr.es\/\" target=\"_blank\" rel=\"noopener noreferrer\">Universidad de Granada<\/a>, Spain, have resurrected ancestral enzymes in both the lab and in computer simulations. The team found that these primitive enzymes possess many desirable characteristics that can be used to develop sustainable biotechnologies.<\/p>\n<p>The researchers <a href=\"https:\/\/pubs.rsc.org\/en\/content\/articlelanding\/2020\/sc\/d0sc01935f#!divAbstract\" target=\"_blank\" rel=\"noopener noreferrer\">successfully repurposed ancient antibiotic-degrading enzymes<\/a> to catalyse a completely new non-natural reaction. However, despite the repurposed enzymes speeding up the reaction significantly, it was much slower than most naturally occurring enzymes.<\/p>\n<h3>Computer-aided biotechnology<\/h3>\n<p>In order to improve upon enzyme efficiency, researchers used powerful computers to calculate how the enzyme can be changed to produce the best result. Using a new method, named FuncLib, the research team used a combination of evolutionary information and calculations of protein stability, to successfully predict more efficient enzyme variants.<\/p>\n<p>Using FuncLib, the team studied 3,000 new enzyme variants and selected 20 of the most promising variants to be used in further lab studies. Researchers discovered that four of these enzymes were much faster than the original enzyme. The best was as effective as the average modern, naturally occurring enzymes.<\/p>\n<p>\u201cOur study shows that it is possible to design new, effective enzymes for a more sustainable future,\u201d says Lynn Kamerlin.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A team of researchers led by Uppsala University, Sweden, have resurrected and reprogrammed an ancient enzyme that can be used to develop sustainable biotechnologies. The team suggest that the billion-year-old enzyme can be reprogrammed to help scientists develop a variety of sustainable biotechnologies, such as bioreactors and toxin degrading mechanisms. \u201cWe use software to simulate [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":5510,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[766,24429],"tags":[3475],"acf":[],"yoast_head":"\n<title>Scientists reprogramme ancient enzyme for sustainable biotechnology<\/title>\n<meta name=\"description\" content=\"A team of researchers led by Uppsala University have resurrected and reprogrammed an ancient enzyme that can be used to develop sustainable biotechnologies.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.innovationnewsnetwork.com\/scientists-reprogramme-ancient-enzyme-for-sustainable-biotechnology\/5509\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Scientists reprogramme ancient enzyme for sustainable biotechnology\" \/>\n<meta property=\"og:description\" content=\"A team of researchers led by Uppsala University have resurrected and reprogrammed an ancient enzyme that can be used to develop sustainable biotechnologies.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.innovationnewsnetwork.com\/scientists-reprogramme-ancient-enzyme-for-sustainable-biotechnology\/5509\/\" \/>\n<meta property=\"og:site_name\" content=\"Innovation News Network\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/InnoNewsNetwork\" \/>\n<meta property=\"article:published_time\" content=\"2020-06-12T10:00:08+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-06-12T08:46:06+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.innovationnewsnetwork.com\/wp-content\/uploads\/2020\/06\/sustainable-biotechnology.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"1080\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Caitlin Magee\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@InnoNewsNetwork\" \/>\n<meta name=\"twitter:site\" content=\"@InnoNewsNetwork\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Caitlin Magee\" \/>\n\t<meta name=\"twitter:label2\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.innovationnewsnetwork.com\/scientists-reprogramme-ancient-enzyme-for-sustainable-biotechnology\/5509\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.innovationnewsnetwork.com\/scientists-reprogramme-ancient-enzyme-for-sustainable-biotechnology\/5509\/\"},\"author\":{\"name\":\"Caitlin Magee\",\"@id\":\"https:\/\/www.innovationnewsnetwork.com\/#\/schema\/person\/5186ad57c79ad5162638977775a065d2\"},\"headline\":\"Scientists reprogramme ancient enzyme for sustainable biotechnology\",\"datePublished\":\"2020-06-12T10:00:08+00:00\",\"dateModified\":\"2020-06-12T08:46:06+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.innovationnewsnetwork.com\/scientists-reprogramme-ancient-enzyme-for-sustainable-biotechnology\/5509\/\"},\"wordCount\":345,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/www.innovationnewsnetwork.com\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.innovationnewsnetwork.com\/scientists-reprogramme-ancient-enzyme-for-sustainable-biotechnology\/5509\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.innovationnewsnetwork.com\/wp-content\/uploads\/2020\/06\/sustainable-biotechnology.jpg\",\"keywords\":[\"Biology\"],\"articleSection\":[\"Research &amp; 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