{"id":5267,"date":"2020-05-27T14:33:54","date_gmt":"2020-05-27T13:33:54","guid":{"rendered":"https:\/\/www.innovationnewsnetwork.com\/?p=5267"},"modified":"2020-05-28T08:41:50","modified_gmt":"2020-05-28T07:41:50","slug":"exchanging-genes-for-the-first-time-using-crispr-cas-technology","status":"publish","type":"post","link":"https:\/\/www.innovationnewsnetwork.com\/exchanging-genes-for-the-first-time-using-crispr-cas-technology\/5267\/","title":{"rendered":"Exchanging genes for the first time using CRISPR\/Cas technology"},"content":{"rendered":"<h2>For the first time, a team of researchers have not only exchange single genes but recombined entire chromosomes with the CRISPR\/Cas technology.<\/h2>\n<p>As reported in <a href=\"https:\/\/www.nature.com\/articles\/s41477-020-0663-x\" target=\"_blank\" rel=\"noopener noreferrer\"><em>Nature Plants<\/em><\/a>, a team from <a href=\"https:\/\/www.kit.edu\/english\/\" target=\"_blank\" rel=\"noopener noreferrer\">Karlsruhe Institute of Technology<\/a> (KIT) and the Leibniz Institute of Plant Genetics and Crop Plant Research (IPK) has developed molecular scissors using CRISPR\/Cas technology. This new development functions as a fine surgical instrument and can be used to <a href=\"https:\/\/www.innovationnewsnetwork.com\/rna-prediction\/967\/\">modify genetic information<\/a> in plants.<\/p>\n<h3>A pioneer of genome editing<\/h3>\n<p>Molecular biologist Professor Holger Puchta has dedicated his studies to discovering how plants can be cultivated more quickly and more precisely. For his <a href=\"https:\/\/cordis.europa.eu\/project\/id\/741306\/de\" target=\"_blank\" rel=\"noopener noreferrer\">CRISBREED project<\/a>, Puchta received an Advanced Grant of the European Research Council (ERC) in the amount of \u20ac2.5m.<\/p>\n<p>Puchta is considered a pioneer of genome editing. He uses molecular scissors to modify the DNA that carries the genetic information in crops. With the help of this new CRISPR\/Cas technology, genes can be removed, inserted, or exchanged easily.<\/p>\n<p>CRISPR\/Cas stands for a certain section on the DNA (CRISPR \u2013 <a href=\"https:\/\/www.innovationnewsnetwork.com\/new-technology-can-simultaneously-run-thousands-of-tests-for-covid-19\/5203\/\">Clustered Regularly Interspaced Short Palindromic Repeats<\/a>) and an enzyme (Cas) that recognises this section and cuts the DNA precisely at this point. Crops produced by genome editing do not contain any DNA, which is why they are not to be equated with classical genetically modified organisms.<\/p>\n<h3>Exchanging arms between chromosomes<\/h3>\n<p>Within CRISBREED, researchers of the Chair for Molecular Biology and Biochemistry of KIT\u2019s Botanical Institute headed by Puchta, in cooperation with Professor Andreas Houben from IPK, Gatersleben, have now achieved first decisive progress in using the molecular CRISPR\/Cas scissors.<\/p>\n<p>For the first time, they have exchanged arms between chromosomes of the thale cress model plant (<em>Arabidopsis thaliana<\/em>) with the help of the Cas9 protein originating from the Staphylococcus aureus bacterium. Puchta explains: \u201cThe genome consists of a certain number of chromosomes, on which the individual genes are arranged in fixed order.<\/p>\n<p>\u201cSo far, CRISPR\/Cas has enabled modifications of single genes only. Now, we can modify and recombine entire chromosomes. We now have the possibility to specifically control the modification of chromosomes and to strengthen or loosen the links between properties. This controlled restructuring of the genome will revolutionise future crop cultivation.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>For the first time, a team of researchers have not only exchange single genes but recombined entire chromosomes with the CRISPR\/Cas technology. As reported in Nature Plants, a team from Karlsruhe Institute of Technology (KIT) and the Leibniz Institute of Plant Genetics and Crop Plant Research (IPK) has developed molecular scissors using CRISPR\/Cas technology. This [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":5268,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[766,24429],"tags":[3475],"acf":[],"yoast_head":"\n<title>Exchanging genes for the first time using CRISPR\/Cas technology<\/title>\n<meta name=\"description\" content=\"For the first time, a team of researchers have not only exchange single genes but recombined entire chromosomes with the CRISPR\/Cas technology.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.innovationnewsnetwork.com\/exchanging-genes-for-the-first-time-using-crispr-cas-technology\/5267\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Exchanging genes for the first time using CRISPR\/Cas technology\" \/>\n<meta property=\"og:description\" content=\"For the first time, a team of researchers have not only exchange single genes but recombined entire chromosomes with the CRISPR\/Cas technology.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.innovationnewsnetwork.com\/exchanging-genes-for-the-first-time-using-crispr-cas-technology\/5267\/\" \/>\n<meta property=\"og:site_name\" content=\"Innovation News Network\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/InnoNewsNetwork\" \/>\n<meta property=\"article:published_time\" content=\"2020-05-27T13:33:54+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-05-28T07:41:50+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.innovationnewsnetwork.com\/wp-content\/uploads\/2020\/05\/CRISPR-Cas-technology.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"1080\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Caitlin Magee\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@InnoNewsNetwork\" \/>\n<meta name=\"twitter:site\" content=\"@InnoNewsNetwork\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Caitlin Magee\" \/>\n\t<meta name=\"twitter:label2\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.innovationnewsnetwork.com\/exchanging-genes-for-the-first-time-using-crispr-cas-technology\/5267\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.innovationnewsnetwork.com\/exchanging-genes-for-the-first-time-using-crispr-cas-technology\/5267\/\"},\"author\":{\"name\":\"Caitlin Magee\",\"@id\":\"https:\/\/www.innovationnewsnetwork.com\/#\/schema\/person\/5186ad57c79ad5162638977775a065d2\"},\"headline\":\"Exchanging genes for the first time using CRISPR\/Cas technology\",\"datePublished\":\"2020-05-27T13:33:54+00:00\",\"dateModified\":\"2020-05-28T07:41:50+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.innovationnewsnetwork.com\/exchanging-genes-for-the-first-time-using-crispr-cas-technology\/5267\/\"},\"wordCount\":376,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/www.innovationnewsnetwork.com\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.innovationnewsnetwork.com\/exchanging-genes-for-the-first-time-using-crispr-cas-technology\/5267\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.innovationnewsnetwork.com\/wp-content\/uploads\/2020\/05\/CRISPR-Cas-technology.jpg\",\"keywords\":[\"Biology\"],\"articleSection\":[\"Research &amp; 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