{"id":51117,"date":"2024-09-12T09:21:08","date_gmt":"2024-09-12T08:21:08","guid":{"rendered":"https:\/\/www.innovationnewsnetwork.com\/?p=51117"},"modified":"2024-09-12T09:21:08","modified_gmt":"2024-09-12T08:21:08","slug":"cutting-edge-tubular-scaffolds-enhance-bone-regeneration","status":"publish","type":"post","link":"https:\/\/www.innovationnewsnetwork.com\/cutting-edge-tubular-scaffolds-enhance-bone-regeneration\/51117\/","title":{"rendered":"Cutting-edge tubular scaffolds enhance bone regeneration"},"content":{"rendered":"<h2>Scientists from Sun Yat-sen University\u2019s School of Biomedical Engineering have made a significant breakthrough in the field of bone regeneration.<\/h2>\n<p>By developing <a href=\"https:\/\/iopscience.iop.org\/article\/10.1088\/2752-5724\/ad66ea\" target=\"_blank\" rel=\"noopener\">advanced tubular scaffolds using electrospun membranes<\/a>, they have created a cutting-edge solution to promote the healing of critical skull defects.<\/p>\n<p>These scaffolds, designed to mimic the structure of natural bone, provide an ideal environment for stem cells to flourish and accelerate the healing process, marking a major step forward in <a href=\"https:\/\/www.innovationnewsnetwork.com\/trinity-college-dublin-secures-e800000-wellcome-award-for-tissue-engineering-research\/50728\/\">tissue engineering<\/a> and regenerative medicine.<\/p>\n<h3>Addressing critical bone defects<\/h3>\n<p>Critical-sized bone defects have long been a major challenge in the medical world. Traditional treatments, such as autografts and allografts, often face limitations, including the scarcity of donors, size mismatches, and potential immune rejection.<\/p>\n<p>These issues have hindered the widespread use of these methods for bone repair. However, the growing field of bone tissue engineering offers a promising solution.<\/p>\n<p>Adipose-derived stem cells (ADSCs), which are easily accessible and possess strong osteogenic (bone-forming) capabilities, have attracted significant attention for their potential in bone regeneration.<\/p>\n<p>While injecting ADSCs directly into defect sites often results in a short survival time, combining them with scaffold materials has proven to enhance retention and improve bone regeneration.<\/p>\n<p>Researchers are now exploring new ways to develop scaffolds that mimic the natural structure of bone, utilising methods like electrospinning and 3D printing.<\/p>\n<h3>Innovative tubular scaffolds for bone regeneration<\/h3>\n<p>The team at Sun Yat-sen University tackled these challenges head-on by developing multilayer composite nanofibrous membranes made from polycaprolactone (PCL), poly(lactic-co-glycolic acid) (PLGA), and nano-hydroxyapatite (HAp).<\/p>\n<p>These materials, created using electrospinning technology, are engineered to replicate the structure of bone. When shaped into tubular scaffolds, they create an optimal environment for adipose-derived stem cells (rADSCs) to promote bone regeneration.<\/p>\n<p>The scaffolds not only simulate bone structure but also enhance the proliferation and osteogenic differentiation of rADSCs, meaning they help these stem cells transform into bone-forming cells more effectively.<\/p>\n<p>In laboratory and animal studies, the scaffolds demonstrated remarkable results in promoting bone growth and healing.<\/p>\n<p>With a bilayer thickness ratio of 1:2 and an initial total thickness of 2.5 \u03bcm, these materials can spontaneously transform into 3D scaffolds when exposed to certain conditions, adding to their practicality in medical applications.<\/p>\n<h3>The future of bone regeneration<\/h3>\n<p>The success of these scaffolds points to a bright future for bone regeneration treatments. The research has shed light on the mechanisms behind how these scaffolds, combined with growth factors like VEGF and BMP-2, promote bone formation.<\/p>\n<p>By integrating both chemical signals and physical properties, these advanced scaffolds have the potential to revolutionise bone defect repair.<\/p>\n<p>Further research is needed to optimise the design of these fibrous scaffolds and explore the mechanisms by which mesenchymal stem cells (MSCs) promote bone regeneration.<\/p>\n<p>However, the results thus far are highly promising, offering a new approach to treating bone defects that could soon be applied in clinical settings.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Scientists from Sun Yat-sen University have made a significant breakthrough in the field of bone regeneration. Find out more.<\/p>\n","protected":false},"author":15,"featured_media":51118,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[10551],"tags":[24183,24166],"acf":[],"yoast_head":"\n<title>Cutting-edge tubular scaffolds enhance bone regeneration<\/title>\n<meta name=\"description\" content=\"Scientists from Sun Yat-sen University have made a significant breakthrough in the field of bone regeneration. 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