{"id":48873,"date":"2024-07-02T09:36:00","date_gmt":"2024-07-02T08:36:00","guid":{"rendered":"https:\/\/www.innovationnewsnetwork.com\/?p=48873"},"modified":"2024-07-02T09:36:00","modified_gmt":"2024-07-02T08:36:00","slug":"nih-sponsored-trial-of-nasal-covid-19-vaccine-opens","status":"publish","type":"post","link":"https:\/\/www.innovationnewsnetwork.com\/nih-sponsored-trial-of-nasal-covid-19-vaccine-opens\/48873\/","title":{"rendered":"NIH-sponsored trial of nasal COVID-19 vaccine opens"},"content":{"rendered":"<h2>A Phase 1 trial testing the safety of an experimental nasal vaccine that may provide enhanced breadth of protection against emerging variants of SARS-CoV-2, the virus that causes COVID-19, is now enrolling healthy adults at three sites in the US.<\/h2>\n<p>The National Institutes of Health (NIH) is <a href=\"https:\/\/www.clinicaltrials.gov\/study\/NCT06441968?term=NCT06441968&amp;rank=1\" target=\"_blank\" rel=\"noopener\">sponsoring the first-in-human trial<\/a> of the nasal COVID-19 vaccine, which was designed and tested in pre-clinical studies by scientists from NIH\u2019s National Institute of Allergy and Infectious Diseases (NIAID) Laboratory of Infectious Diseases.<\/p>\n<p>\u201cThe rapid development of safe and effective COVID-19 vaccines was a triumph of science, and their use greatly mitigated the toll of the pandemic,\u201d said NIAID Director Jeanne Marrazzo.<\/p>\n<p>\u201cWhile first-generation COVID-19 vaccines continue to be effective at preventing severe illness, hospitalisations, and death, they are less successful at preventing infection and milder forms of disease.<\/p>\n<p>\u201cWith the continual <a href=\"https:\/\/www.innovationnewsnetwork.com\/emerging-covid-19-variants-identified-with-ai\/45174\/\">emergence of new virus variants<\/a>, there is a critical need to develop next-generation COVID-19 vaccines, including nasal vaccines, that could reduce SARS-CoV-2 infections and transmission.\u201d<\/p>\n<h3>Rolling out clinical trials of the vaccine<\/h3>\n<p>The study aims to enrol 60 adult participants, ages 18 to 64, who have previously received at least three doses of an FDA-approved mRNA COVID-19 vaccine.<\/p>\n<p>Study volunteers will be divided into three cohorts. The first cohort will receive one dose of the investigational vaccine delivered in a nasal spray at the lowest dosage, with participants in the next two cohorts receiving progressively higher doses.<\/p>\n<p>During seven follow-up visits over about one year, scientists will measure how well the candidate tolerates the nasal vaccine and whether it generates an immune response in the blood and nose.<\/p>\n<h3>How a nasal COVID-19 vaccine works<\/h3>\n<p>The investigational vaccine, MPV\/S-2P, uses murine pneumonia virus (MPV) as a vector to deliver a version of the SARS-CoV-2 spike protein (S-2P) stabilised in its prefusion conformation.<\/p>\n<p>MPV does not cause disease in humans or non-human primates but does have an affinity for epithelial cells that line the respiratory tract.<\/p>\n<p>Therefore, it may be effective in delivering vaccine to the places where natural coronavirus infections begin.<\/p>\n<p>It produced robust systemic immune responses, including SARS-CoV-2-directed antibodies, as well as local immunity in cells in the mucosal tissues lining the nose and respiratory tract.<\/p>\n<p>Studies in humans and animals suggest that mucosal immunity is more effective than systemic immunity in controlling the replication of respiratory viruses.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>An experimental nasal vaccine that may provide enhanced protection against variants of SARS-CoV-2 is now enrolling healthy adults in the US.<\/p>\n","protected":false},"author":22,"featured_media":48874,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[10551],"tags":[16871],"acf":[],"yoast_head":"\n<title>NIH-sponsored trial of nasal COVID-19 vaccine opens<\/title>\n<meta name=\"description\" content=\"An 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