{"id":48555,"date":"2024-06-17T11:39:22","date_gmt":"2024-06-17T10:39:22","guid":{"rendered":"https:\/\/www.innovationnewsnetwork.com\/?p=48555"},"modified":"2024-06-17T11:39:22","modified_gmt":"2024-06-17T10:39:22","slug":"controlling-body-temperature-to-fight-antibiotic-resistance","status":"publish","type":"post","link":"https:\/\/www.innovationnewsnetwork.com\/controlling-body-temperature-to-fight-antibiotic-resistance\/48555\/","title":{"rendered":"Controlling body temperature to fight antibiotic resistance"},"content":{"rendered":"

New research suggests that controlling body temperature could be an effective strategy for curbing antibiotic resistance.<\/h2>\n

Experts from the universities of Groningen, Montpellier, and Oldenburg have investigated how a fever can impact the development of antimicrobial resistance<\/a>.<\/p>\n

Their findings illustrate that a temperature increase from just 37 to 41\u00b0C changed the mutation frequency in E. coli<\/em>\u00a0bacteria significantly, which drives the development of resistance.<\/p>\n

The researchers believe that if these effects can be replicated in humans, a new method for fighting antibiotic resistance could be developed.<\/p>\n

This could be a major breakthrough, as antimicrobial resistance is a global health issue, responsible for 1.27\u00a0million global deaths in 2019 and contributing to 4.95\u00a0million deaths<\/a>.<\/p>\n

Combatting antibiotic resistance<\/h3>\n

There are two ways to combat antibiotic resistance \u2013 developing new drugs or preventing the development of resistance.<\/p>\n

Timo van Eldijk, co-first author of the research, explained: “We know that temperature affects the mutation rate in bacteria.<\/p>\n

“What we wanted to find out was how the increase in temperature associated with fever influences the mutation rate towards antibiotic resistance.”<\/p>\n

To test this hypothesis, the researchers cultured E. coli<\/em> bacteria at 37 or 40\u00b0C and exposed them to three antibiotics with different modes of action: iprofloxacin, rifampicin, and ampicillin.<\/p>\n

The results revealed that higher temperatures increased the mutation rate towards resistance for ciprofloxacin and rifampicin, while ampicillin caused a decrease in the mutation rate at fever temperatures.<\/p>\n

Van Eldijk added: “To be certain of this result, we actually replicated the study with ampicillin in two different labs, at the University of Groningen and the University of Montpellier, and got the same result.”<\/p>\n

Developing fever-suppressing medications<\/h3>\n

The researchers theorised that ampicillin’s efficacy might depend on temperature, and their experiment confirmed this, explaining why resistance to ampicillin is less likely at 40\u00b0C.<\/p>\n

“Our study demonstrates that even a slight temperature change can significantly alter the mutation rate towards antimicrobial resistance,” said Van Eldijk. “Interestingly, other factors like growth rate remain unaffected.”<\/p>\n

If these findings are replicated in humans, it could lead to new strategies for combating antimicrobial resistance.<\/p>\n

This might involve using fever-suppressing drugs to lower temperatures or administering antimicrobial drugs that are more effective at higher temperatures to patients with a fever.<\/p>\n","protected":false},"excerpt":{"rendered":"

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