{"id":48419,"date":"2024-06-11T09:26:10","date_gmt":"2024-06-11T08:26:10","guid":{"rendered":"https:\/\/www.innovationnewsnetwork.com\/?p=48419"},"modified":"2024-06-11T09:32:37","modified_gmt":"2024-06-11T08:32:37","slug":"cyclic-peptides-discovery-to-develop-new-antibiotics-to-fight-amr","status":"publish","type":"post","link":"https:\/\/www.innovationnewsnetwork.com\/cyclic-peptides-discovery-to-develop-new-antibiotics-to-fight-amr\/48419\/","title":{"rendered":"Cyclic peptides discovery could develop new antibiotics to fight AMR"},"content":{"rendered":"<h2>Experts at King&#8217;s College London have made an exciting breakthrough in cyclic peptides that could open the door for developing new antibiotics to combat <a href=\"https:\/\/www.innovationnewsnetwork.com\/infection-control-measures-could-prevent-750000-amr-deaths\/47837\/\">antimicrobial resistance (AMR).<\/a><\/h2>\n<p><a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.4c04711\" target=\"_blank\" rel=\"noopener\">Scientists have developed a new method for rapidly making cyclic peptides<\/a> \u2013 an essential type of antibiotic molecule.<\/p>\n<p>The innovative process takes just minutes instead of hours and even days, which it traditionally takes, significantly speeding up antibiotic development.<\/p>\n<p>Lead author Dr Sarah Barry, from the Department of Chemistry at King&#8217;s College London, explained: &#8220;The global rise in antimicrobial-resistant infections is putting the huge gains in modern medicine over the last century at risk.<\/p>\n<p>&#8220;Everything from a cut in your finger to major surgery or cancer treatment requires the use of antibiotics. But when bacteria and viruses evolve to evade these medicines, these life-saving drugs lose their effectiveness.<\/p>\n<p>&#8220;We urgently need to invest in antibiotic development \u2013 and we hope that breakthroughs like our new method at King&#8217;s can inspire renewed efforts towards this goal.&#8221;<\/p>\n<h3>Challenges in antibiotic development<\/h3>\n<p>Developing novel antibiotics is essential, with the rise of AMR making infectious diseases that were once easy to treat increasingly difficult.<\/p>\n<p>Modifying and creating new antibiotics to combat resistance is challenging due to their complex molecular structure.<\/p>\n<p>This is because some are formed of cyclic peptides, which are strings of amino acids joined in a circle. Recreating them in a lab is extremely difficult.<\/p>\n<h3>A new method for producing cyclic peptides<\/h3>\n<p>The scientists studied a naturally occurring cyclic peptide with promising activity against the bacteria causing TB, the world&#8217;s deadliest and increasingly resistant infectious disease.<\/p>\n<p>They discovered that using the natural peptide&#8217;s amino acid sequence to create synthetic peptides allowed these peptides to form cycles rapidly.<\/p>\n<p>The researchers believe this straightforward method can be applied to modify antimicrobial molecules, paving the way for new antibiotic development.<\/p>\n<p>Dr Yaoyu Ding, a Research Assistant who&#8217;s PhD was based on the project, added: &#8220;We have made a key part of the chemistry involved in making these molecules far easier and quicker.<\/p>\n<p>&#8220;We hope that this chemistry will enable researchers to make libraries of derivates to enable screening for new antimicrobials.&#8221;<\/p>\n<p>The team has also tested this method on other types of peptides, opening possibilities for other classes of drugs, such as anti-cancer agents.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Experts at King College London have created a new method to develop cyclic peptides that could pioneer new antibiotics to combat AMR.<\/p>\n","protected":false},"author":15,"featured_media":48420,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[10551],"tags":[24360,3512],"acf":[],"yoast_head":"\n<title>Cyclic peptides discovery to develop new antibiotics to fight AMR<\/title>\n<meta name=\"description\" content=\"Experts at King&#039;s College London have created a new method to develop cyclic peptides that could pioneer new antibiotics to combat AMR.\" 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