{"id":42306,"date":"2024-01-24T14:53:57","date_gmt":"2024-01-24T14:53:57","guid":{"rendered":"https:\/\/www.innovationnewsnetwork.com\/?p=42306"},"modified":"2024-01-24T14:53:57","modified_gmt":"2024-01-24T14:53:57","slug":"could-combining-two-drugs-be-better-for-treating-prostate-cancer","status":"publish","type":"post","link":"https:\/\/www.innovationnewsnetwork.com\/could-combining-two-drugs-be-better-for-treating-prostate-cancer\/42306\/","title":{"rendered":"Could combining two drugs be better for treating prostate cancer?"},"content":{"rendered":"

A Phase 3 clinical trial led by UC San Francisco researchers discovered that combining testosterone-blocking drugs in patients with prostate cancer relapse is better at treating prostate cancer than treatment with a single drug.<\/h2>\n

Prostate cancer treatment is usually carried out with one of several testosterone-lowering drugs for a set period of time.<\/p>\n

However, the new approach can extend the time between debilitating drug treatments<\/a> without prolonging the time it takes to recover from each treatment.<\/p>\n

\u201cThis adds to a growing body of evidence in favour of more intensive testosterone-blocking therapy for treating prostate cancer,\u201d said Rahul Aggarwal MD, professor in the UCSF School of Medicine and lead author of the paper.<\/p>\n

The research, \u2018Open-Label Study of Intensification of Androgen Blockade in Patients With High-Risk Biochemically Relapsed Castration-Sensitive Prostate Cancer<\/a>,\u2019 was published in the Journal of Clinical Oncology<\/em>.<\/p>\n

A case for intensifying prostate cancer treatment<\/h3>\n

The new study focused on patients who had surgery for prostate cancer, and yet the cancer relapsed and was detected through a sudden jump in the blood levels of a protein called prostate-specific antigen (PSA).<\/p>\n

Aggarwal explained: \u201cWe looked at patients who had a fast rise in their PSA \u2013 an indicator of a higher-risk form of relapsed prostate cancer.<\/p>\n

\u201cOur goal was to test several different hormone therapy strategies to find the best approach in terms of delaying the cancer\u2019s progression.\u201d<\/p>\n

Between 2017 and 2022, 503 patients were randomly assigned to take a single testosterone-lowering therapy chosen by their oncologist or to combine it with one or two other testosterone-lowering drugs.<\/p>\n

The additional drugs were already FDA-approved for other cancers but hadn\u2019t been tested in this way with prostate cancer.<\/p>\n

The patients stayed on the assigned therapy for a year. Whether given singly or in combination, the drugs caused their testosterone to plummet.<\/p>\n

That put the brakes on their cancer but also caused fatigue, hot flashes, decreased libido and other problems for patients, according to Aggarwal.<\/p>\n

Combining drugs could be the new way forward<\/h3>\n

Compared to patients who only received a single drug therapy during their year of prostate cancer treatment, patients who received either one or two additional drugs stayed cancer-free, with low PSA levels for longer.<\/p>\n

Once off the treatment, patients who took the combination therapies saw their testosterone levels recover just as fast as others who took the single drug.<\/p>\n

The researchers are following up with a more detailed analysis of how patients fared when treating prostate cancer \u2013 which side effects they experienced and for how long, and how they felt overall as they recovered.<\/p>\n

Aggarwal concluded: \u201cNew cancer therapies must clear a high bar to make their way to patients.<\/p>\n

\u201cWith the evidence in this study and others, combination hormone therapy should be considered a standard of care in prostate cancer patients with high-risk relapse after prior treatment.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"

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