{"id":38242,"date":"2023-10-16T10:08:27","date_gmt":"2023-10-16T09:08:27","guid":{"rendered":"https:\/\/www.innovationnewsnetwork.com\/?p=38242"},"modified":"2023-10-16T10:08:27","modified_gmt":"2023-10-16T09:08:27","slug":"new-3d-printed-tumour-model-enables-faster-less-painful-cancer-treatment","status":"publish","type":"post","link":"https:\/\/www.innovationnewsnetwork.com\/new-3d-printed-tumour-model-enables-faster-less-painful-cancer-treatment\/38242\/","title":{"rendered":"New 3D-printed tumour model enables faster, cheaper, and less painful cancer treatment"},"content":{"rendered":"

An international team of interdisciplinary researchers has successfully created a 3D-printed tumour model that will better treat complex cancers.<\/h2>\n

The team, led by the University of Waterloo, combined cutting-edge bioprinting techniques with synthetic structures or microfluidic chips to create the 3D-printed tumour model.<\/p>\n

The method will help lab researchers more accurately understand heterogeneous tumours \u2013 tumours with more than one kind of cancer cell, often dispersed in unpredictable patterns.<\/p>\n

A study detailing the research, \u2018Controlled tumour heterogeneity in a co-culture system by 3D bio-printed tumour-on-chip model<\/a>,\u2019 is published in Scientific Reports<\/em>.<\/p>\n

Advancing developments in tumour treatment<\/h3>\n

Traditionally, medical practitioners would biopsy a patient\u2019s tumour, extract cells, and then grow them in flat petri dishes in a lab.<\/p>\n

Nafiseh Moghimi, an applied mathematics post-doctoral researcher and the study’s lead author, explained: \u201cFor 50 years, this was how biologists understood tumours. But a decade ago, repeated treatment failures in human trials made scientists realise that a 2D tumour model does not capture the real tumour structure inside the body.\u201d<\/p>\n

The team\u2019s research addresses this problem by creating a 3D-printed tumour model that not only reflects the complexity of a tumour but simulates its surrounding environment.<\/p>\n

\"3d-printed
\u00a9 shutterstock\/CI Photos<\/figcaption><\/figure>\n

\u201cWe are creating something that is very, very new in Canada. Maybe just a couple of labs are doing something even close to this research,\u201d Moghimi said.<\/p>\n

How was the 3D-printed tumour model created?<\/h3>\n

Firstly, the team created polymer \u2018microfluidic chips\u2019 \u2013 tiny structures etched with channels that mimic blood flow and other fluids surrounding a patient\u2019s tumour.<\/p>\n

Next, the team grew multiple types of cancer cells and suspended these cell cultures in their own customised bioink: a cocktail of gelatine, alginate, and other nutrients designed to keep the cell cultures alive.<\/p>\n

Finally, they used an extrusion bioprinter \u2013 a device that resembles a 3D<\/a> printer but for organic material \u2013 to layer the different types of cancer cells onto the prepared microfluidic chips.<\/p>\n

The result is a living, 3D-printed tumour model of complex cancers that scientists can then use to test different modes of treatment, such as various chemotherapy drugs.<\/p>\n

The tumour model will be focused on breast cancer<\/h3>\n

Moghimi and her team are particularly interested in creating complex models of breast cancer. After skin cancer, breast cancer is the most common cancer diagnosed in women.<\/p>\n

Breast cancer is incredibly challenging to treat because it appears as complex tumours containing multiple types of cells when it metastasises.<\/p>\n

Relying on the cells from one or two biopsies to accurately represent an entire tumour can lead to ineffective treatment plans and poor outcomes.<\/p>\n

The 3D-printed tumour model exemplifies how new technology enables faster, less expensive, and less painful treatments for severe conditions like late-stage cancer<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

Discover more about a 3D-printed tumour model that will more accurately understand and better treat complex cancers.<\/p>\n","protected":false},"author":22,"featured_media":38243,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[10551],"tags":[24493,849],"acf":[],"yoast_head":"\nNew 3D-printed tumour model enables faster, less painful cancer treatment<\/title>\n<meta name=\"description\" content=\"Discover more about a 3D-printed tumour model that will more accurately understand and better treat complex cancers.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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